What is LYO in pharma?
Lyophilization, defined as a freeze-drying process that removes water from a product after it is frozen and placed under a vacuum, is often messy, but filled with possibilities for potential applications. “If the bulk drug ingredients are not stable in liquid or frozen form, lyophilization is necessary.
What are lyophilized products?
INTRODUCTION. Lyophilization or freeze drying is a process in which water is removed from a product after it is frozen and placed under a vacuum, allowing the ice to change directly from solid to vapor without passing through a liquid phase.
How is lyophilized powder made?
A lyophilized powder is a powder made by freeze-drying. Lyophilized powder is a freeze-dried powder.
How do you build LYO cycle?
Development of lyophilization cycle
- Primary drying. Primary drying temperature and primary drying time are the important parameters in primary drying stage.
- Secondary drying. Two parameters are important while optimizing secondary drying secondary drying temperature and secondary drying time.
- Vacuum.
What is LYO?
combining form. indicating dispersion or dissolution: lyophilic; lyophilize; lyophobic. [from Greek luein to loose]
What is lyophilized formulation?
Lyophilization, or freeze drying, is a well-recognized method for obtaining stable biologic drug products that have short shelf-lives in solution form. Lyophilized products are easy to store and ship. Because freeze-drying is a low-temperature process, thermal degradation is minimized.
Is lyophilization the same as freeze-drying?
Lyophilization and freeze drying are terms that are used interchangeably depending on the industry and location where the drying is taking place. Controlled freeze drying keeps the product temperature low enough during the process to avoid changes in the dried product appearance and characteristics.
Is liposomal same as lyophilized?
While lyophilization is a mature pharmaceutical technology, liposome-specific lyophilization platforms must be developed using particular lyophilization experience and strategies.
What is the principle of freeze drying?
The fundamental principle in freeze-drying is sublimation, the shift from a solid directly into a gas. Just like evaporation, sublimation occurs when a molecule gains enough energy to break free from the molecules around it.
Can you freeze dry DMSO?
Dissolved in water, DMSO has an incredibly high freezing point (just below room temperature), which makes it a good candidate for freeze drying. If DMSO is dissolved in a solvent, remove the solvent with an evaporator before lyophilizing.
Is LYO a word?
indicating dispersion or dissolution: lyophilic; lyophilize; lyophobic.
How do you use the production possibilities model?
Use the production possibilities model to distinguish between full employment and situations of idle factors of production and between efficient and inefficient production. Understand specialization and its relationship to the production possibilities model and comparative advantage.
Do you need a closed tray for lyophilization?
“Consider using a closed tray in lyophilization chambers. Using a closed tray can prevent product flyout during the filling, transportation, and lyophilization process, which reduces dryer cleaning time and validation of cleaning procedure,” said Robinson. Typically, lyophilization occurs in three stages:
What do you need to know about lyophilization?
Lyophilization, defined as a freeze-drying process that removes water from a product after it is frozen and placed under a vacuum, is often messy, but filled with possibilities for potential applications.
How is the production possibilities curve related to scarcity?
A production possibilities curve shows the combinations of two goods an economy is capable of producing. The downward slope of the production possibilities curve is an implication of scarcity. The bowed-out shape of the production possibilities curve results from allocating resources based on comparative advantage.