How is erythromycin synthesized?
Most methods for the Erythromycin synthesis are based on the con- struction of the aglycon from secoic acid via gly- cosylation. Indeed the process is also possible in- versely: first, a glycosylation, then a lactonization occurs. The yield, however, is considerably less.
What is the pharmacokinetics of erythromycin?
Pharmacokinetics. Erythromycin is easily inactivated by gastric acid; therefore, all orally administered formulations are given as either enteric-coated or more-stable salts or esters, such as erythromycin ethylsuccinate. Erythromycin is very rapidly absorbed, and diffuses into most tissues and phagocytes.
Is erythromycin an antibiotic or steroid?
Erythromycin is known as a macrolide antibiotic. It works by stopping the growth of bacteria. This antibiotic treats or prevents only bacterial infections. It will not work for viral infections (such as common cold, flu).
What does erythromycin do to protein synthesis?
Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother.
What can erythromycin cure?
About erythromycin Erythromycin is an antibiotic. It’s widely used to treat chest infections, such as pneumonia, skin problems, such as acne and rosacea, dental abscesses, and sexually transmitted infections. Erythromycin is used in children, often to treat ear infections or chest infections.
What erythromycin works for?
How is erythromycin biosynthesis related to global regulation?
These findings help to understand the global regulation mechanisms of erythromycin biosynthesis in S. erythraea, providing useful clues for genetic and metabolic enginee … This is a demonstration of the functional comparative genomics between an industrial S. erythraea strain and the wild-type strain.
Why is comparative genomics important for Erythromycin biosynthesis?
This is a demonstration of the functional comparative genomics between an industrial S. erythraea strain and the wild-type strain. These findings help to understand the global regulation mechanisms of erythromycin biosynthesis in S. erythraea, providing useful clues for genetic and metabolic enginee …
What kind of bacteria is used to make erythromycin?
Background: S. erythraea is a Gram-positive filamentous bacterium used for the industrial-scale production of erythromycin A which is of high clinical importance.
Where does the biosynthesis of steroids take place?
Steroid biosynthesis begins with the transfer of free cholesterol from intracellular stores into the inner mitochondrial membrane, where it is transformed into pregnenolone (see Fig. 119-7 ).