What is insulin desensitization?

What is insulin desensitization?

Desensitization of insulin secretion describes a reversible state of decreased secretory responsiveness of the pancreatic beta-cell, induced by a prolonged exposure to a multitude of stimuli.

What is hypersensitivity to insulin?

Hypersensitivity to insulin or insulin analogues can occur in all age groups and in patients with either type 1 or type 2 diabetes and includes local reactions, systemic reactions, and, rarely, true allergic reactions.

How do you control an insulin allergy?

As a rule, allergy may be treated with antihistamines. Some cases may require epinephrine and intravenous (IV) steroids. Local allergic reactions can occur at the site of insulin injections and can cause pain, burning, local erythema, pruritus, and induration.

Can you be allergic to your own insulin?

Allergic reactions to insulin are rare, but they do exist.

What causes insulin desensitization?

Prolonged stimulation of insulin secretion by depolarization and Ca2+ influx regularly leads to a reversible state of decreased secretory responsiveness to nutrient and nonnutrient stimuli. This state is termed “desensitization.” The onset of desensitization may occur within 1 h of exposure to depolarizing stimuli.

What are the adverse reactions associated with insulin?

Insulin regular (human) side effects

• sweating.
• dizziness or lightheadedness.
• shakiness.
• hunger.
• fast heart rate.
• tingling in your hands, feet, lips, or tongue.
• trouble concentrating or confusion.
• blurred vision.

Is it good to be insulin sensitive?

If you have insulin resistance, you have low insulin sensitivity. Conversely, if you are sensitive to insulin, you have low insulin resistance. While insulin resistance is harmful to your health, insulin sensitivity is beneficial.

What can be used instead of insulin?

There are six types of non-insulin medicines used to treat type 2 diabetes:

• Metformin: Pills that reduce sugar production from the liver.
• Thiazolidinediones (glitazones):
• Insulin releasing pills (secretagogues):
• Starch blockers:
• Incretin based therapies:
• Amylin analogs:

Can you be allergic to Levemir insulin?

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

What is the most common treatment for Type I diabetes?

Treatment for type 1 diabetes includes:

• Taking insulin.
• Carbohydrate, fat and protein counting.
• Frequent blood sugar monitoring.
• Eating healthy foods.
• Exercising regularly and maintaining a healthy weight.

What happens if receptors of cells become desensitized to insulin?

Upon binding of insulin, the desensitized receptors are internalized rapidly, with characteristics indistinguishable from those of control cells. In contrast, this desensitization is accompanied by a loss of the insulin-sensitive tyrosine kinase activity of insulin receptors isolated from these cells.

How does Levemir work as an insulin injection?

LEVEMIR®(insulin detemir [rDNA origin] injection) is a sterile solution of insulin detemir for use as an injection. Insulin detemir is a long-acting basal insulin analog, with up to 24 hours duration of action, produced by a process that includes expression of recombinant DNA in Saccharomyces cerevisiae followed by chemical modification.

Can you use Levemir in combination with Lantus?

Insulin detemir (Levemir) joins insulin glargine (Lantus) as the only other long-acting insulin analogue approved as basal therapy for the treatment of diabetes mellitus. It is indicated for use in adults and children in combination with short-acting insulin for type 1 diabetes…

How is human insulin used for desensitization?

We treated the patient with human insulin using an ultra-rush protocol beginning with 0.004 IU and a rapid augmentation in dose up to 5 IU. Therapy was accompanied by antihistamine therapy. Subsequent conversion to therapy with glargine insulin (6 IE twice daily) was well-tolerated.

What is the bioavailability of Levemir in the blood?

The absolute bioavailability of insulin detemir is approximately 60%. Distribution and Elimination More than 98% insulin detemir in the bloodstream is bound to albumin. LEVEMIR has a small apparent volume of distribution of approximately 0.1 L/kg.