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What is AIH PBC?

What is AIH PBC?

Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are two major immune-mediated chronic liver diseases that can be differentiated using clinical, biochemical, serologic, and histologic findings. 1, 2 However, a group of patients may have characteristics of both either simultaneously or consecutively.

Can you be misdiagnosed with PBC?

As mentioned, PBC can often go unnoticed or, more commonly, misdiagnosed, leaving patients’ symptoms to develop and cause further damage to their body.

What does PBC disease stand for?

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic liver disease resulting from progressive destruction of the bile ducts in the liver – called the intrahepatic bile ducts.

What happens if PBC is not treated?

If PBC is untreated or there is incomplete response to medical treatment, it can lead to cirrhosis (e.g., scarring of the entire liver), which can lead to liver failure. PBC is divided into four stages from stage 1 (early disease, without significant scarring of the liver) to stage 4 (cirrhosis).

Does PBC cause joint pain?

Most people are only diagnosed with PBC after having a routine blood test for another reason. Some people have symptoms early on and some may develop them later. People who have symptoms may experience: bone or joint aches.

Can I live a long life with PBC?

If a person with PBC has advanced symptoms as seen in an advanced stage, the average life expectancy is about 10-15 years . However, everyone is different. Some people live longer than others with the disease. New treatments are improving the outlook for people with PBC.

How fast does PBC progress?

It is important to note that, for most people, PBC progresses slowly from one phase to the next. People can have the disease for a decade or more before they reach cirrhosis. In people who do not treat their PBC, the disease may progress from one stage to the next as fast as every 1.5 years.

Is there a cure for AMA negative PBC?

Accordingly, this disease is often referred to as “AMA-negative PBC”. Some studies demonstrate that people with autoimmune cholangitis benefit from treatment with prednisone, either alone or in combination with azathioprine.

Is there a diagnostic marker for PBC or PSC?

Unlike the presence of AMA as a diagnostic marker in people with PBC, there are no diagnostic autoantibodies that occur in people with PSC. Instead, PSC requires a special procedure called an endoscopic retrograde cholangiopancreatography (ERCP) to be done in order for the disease to be accurately diagnosed.

Are there any similarities between PBC and PSC?

Symptoms of PBC and PSC may overlap, as fatigue and itching are common to people with either disease. There is a drastic difference in the way that the two diseases are diagnosed.

Is there a link between PBC and AIH?

This is because there is such a strong association of AMA with PBC. In fact, it has been demonstrated that features of AIH in people with PBC may be transient. Furthermore, response to UDCA appears to be similar in people with PBC with and without features of AIH.

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