What are co processed excipients?
“ A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of covalent bonds. Co- processed excipients have functionalities that are not achievable through sample blending”.
Which of following is commonly used for direct compression?
Microcrystalline cellulose is used in direct compression as a strong dry binder, tablet disintegrants, an absorbent, a lubricant, and anti-adherent. It is also used as a diluent in tablets prepared by wet granulation, as filler in capsules and for the production of spheres.
Are binders excipients?
Binder excipients hold the ingredients of a formulation together, for example in a tablet. Binders ensure that tablets, powders, granules and others can be formed with the required mechanical strength. Moreover, they give volume to low active dose tablets.
What is excipients in pharma?
Pharmaceutical excipients are substances that are included in a pharmaceutical dosage form not for their direct therapeutic action, but to aid the manufacturing process, to protect, support or enhance stability, or for bioavailability or patient acceptability.
What is Ludipress?
Ludipress combines the three functionalities of a filler, binder and disintegrant in a ready-to-use excipient for tabletting using the direct compression technology. Ludipress is composed of Lactose monohydrate, Povidone K30 (Kollidon® 30) and Crospovidone (Kollidon CL).
What is co processing waste?
Geocycle offers waste treatment solutions based on a unique industrial process called co-processing. It refers to the simultaneous recycling of mineral materials and recovery of energy within one single industrial process: cement manufacturing.
What are the three stages of direct compression?
Typically, direct compression process consists of three steps: raw material blending, tableting, and coating. These steps are interconnected in continuous processes, so that the raw materials are fed into the process, and the tablets are obtained from the process simultaneously.
What is the purpose of direct compression method?
By simply mixing in a blender, formulation ingredients can be processed and compressed into tablets without any of the ingredients having to be changed. This procedure is called direct compression and it is used in the manufacture of tablets when formulation ingredients can flow uniformly into a die cavity.
Is magnesium stearate a glidant?
Magnesium stearate, a metallic salt boundary lubricant, is probably the most commonly used lubricant for pharmaceutical tableting; it is relatively inexpensive, provides high lubrication, has a high melting point, and is chemically stable (2). Stearic acid is the most commonly used fatty acid boundary lubricant.
What are the different types of excipients?
Types of Excipients
- Antioxidants.
- Binders. Dry binders. Wet or Solution binders.
- Coating Agents.
- Colours and Pigments. Dyes. Lakes.
- Bulking Agents / Dilutents / Fillers.
- Disintegrants.
- Emollients.
- Emulsifying agents.
Why are co processed excipients considered to be safe?
The co-processed excipients retain favourable attributes and are supplemented with new ones. As the chemical change is absent, they are considered to retain the “GRAS” (Generally Regarded as Safe) status. Co-processed excipients are believed to bring a drastic change in the field of pharmaceutical Research.
What makes a co processed excipient a Gras grade?
Co -processed ex cipients grade excipients. The co-processed excipients retain favourable attributes and are supplemented with new ones. As the ch emical change is absent, they are considered to retain th e “GRAS” (Generally Regarded as Safe) status. Co-processed
Which is the best method to prepare directly compressible excipients?
The co-processing is the most widely explored method for the preparation of directly compressible adjuvants because it is cost effective and can be prepared in-house based on the functionality required. Hence, the present review focuses on the properties of the co-processed directly compressible adjuvants available in the market.
Where can I find co processed excipients in India?
1 Department of Pharmaceutics, ST. Mary’s Group of Institutions Guntur, Chebrolu (V& M), Guntur (Dt), Andhra Pradesh, India – 522212. 2 Department of Pharmaceutical Chemistry, ST. Mary’s Group of Institutions Guntur, Chebrolu (V& M), Guntur (Dt), Andhra Pradesh, India – 522212. approaches involved in development of such excipients.