Is nifedipine water soluble?
Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dimethyl ester, C17H18N2O6, and has the structural formula: Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.3.
Why is nifedipine contraindicated in angina?
Immediate-release nifedipine should be avoided in certain coronary artery disease states which include cardiogenic shock or acute myocardial infarction (or other acute coronary syndromes such as unstable angina) due to its negative inotropic effects and the reflex sympathetic activation, tachycardia, and hypotension …
What is the mechanism of action for nifedipine?
Mechanism of Action: The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance.
How is nifedipine absorbed?
Nifedipine is almost completely absorbed from the gastrointestinal tract as shown by plasma levels after sublingual, oral, and rectal administration. Because of presystemic metabolism, the bioavailability is about 56% to 77%.
Can I take nifedipine at night?
You can take nifedipine at any time of day, but try to make sure it’s around the same time or times every day. Swallow the capsules or tablets whole with a drink of water. Do not break, crush, chew or open up the capsules unless your doctor or pharmacist has said you can.
How fast does nifedipine work?
Nifedipine starts to work on the day you start taking it, but it may take a couple of weeks fully take effect. If you’re taking nifedipine for high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take it.
What foods should be avoided when taking nifedipine?
Should I avoid any foods or drinks while taking nifedipine? Avoid drinking grapefruit juice or eating a lot of grapefruit while you are taking nifedipine. Grapefruit juice can increase the amount of nifedipine in your blood and so increase the risk of you getting side effects.
Does nifedipine work immediately?
How long does nifedipine take to work? Nifedipine starts to work on the day you start taking it, but it may take a couple of weeks fully take effect. If you’re taking nifedipine for high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take it.
What kind of solvent is nifedipine soluble in?
Nifedipine is soluble (g/L, at 20°C) in the following solvents: acetone, 250; methylene chloride, 160; chloroform, 140; ethyl acetate, 50; methanol, 26; ethanol, 17.4 It is practically insoluble in water.
Are there any side effects to taking nifedipine?
Drug Warning. Nifedipine-induced peripheral edema of the lower extremities usually responds to diuretic therapy. The relatively common adverse effects reported with conventional liquid-filled (short-acting) nifedipine capsules are similar in nature to those reported with extended-release tablets of the drug.
What is the half life of nifedipine capsules?
The elimination half-life of nifedipine is approximately two hours. Since hepatic biotransformation is the predominant route for the disposition of nifedipine, the pharmacokinetics may be altered in patients with chronic liver disease.
What is the mechanism of action of nifedipine?
Laboratory Chemical Safety Summary (LCSS) Nifedipine is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Nifedipine is a Dihydropyridine Calcium Channel Blocker. The mechanism of action of nifedipine is as a Calcium Channel Antagonist.