What does Golgi tendon do?
When people lift weights, the golgi tendon organ is the sense organ that tells how much tension the muscle is exerting. If there is too much muscle tension the golgi tendon organ will inhibit the muscle from creating any force (via a reflex arc), thus protecting the you from injuring itself.
What does muscle spindle do?
Muscle spindles are proprioceptors that consist of intrafusal muscle fibers enclosed in a sheath (spindle). They run parallel to the extrafusal muscle fibers and act as receptors that provide information on muscle length and the rate of change in muscle length. The spindles are stretched when the muscle lengthens.
How does the Golgi tendon reflex work?
The Golgi tendon reflex operates as a protective feedback mechanism to control the tension of an active muscle by causing relaxation before the tendon tension becomes high enough to cause damage. Second, the motor neuron from the spinal cord is inhibited via an IPSP and muscle relaxes.
What is the difference between Golgi tendon organs and muscle spindles?
The key difference between muscle spindle and Golgi tendon organ is that muscle spindle is a sensory organ that senses the changes in muscle length and the rate of lengthening, while Golgi tendon organ is a sensory organ that senses the changes in muscle tension.
How is receptor induced fragmentation of the Golgi?
We show that receptor induced G protein βγ subunit translocation from the plasma membrane to the Golgi allows a receptor to initiate fragmentation and regulate secretion. A lung epithelial cell line, A549, was shown to contain an endogenous translocating G protein γ subunit and exhibit receptor-induced Golgi fragmentation.
How does GPCRs regulate the function of the Golgi?
The recent observation that specific βγ complexes translocate to the Golgi on activation by an extracellular signal ( 1 – 3) suggested that GPCRs on the plasma membrane may regulate the function of intracellular Golgi membranes through this translocation.
Is the Golgi SNAP receptor part of the NSF family?
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
What is the function of the Golgi tendon organ?
The Golgi tendon organ (GTO) (also called Golgi organ, tendon organ, neurotendinous organ or neurotendinous spindle) is a proprioceptor – a type of sensory receptor that senses changes in muscle tension. It lies at the interface between a muscle and its tendon known as the myotendinous junction.