What is Nevoid hypopigmentation?
Abstract. Linear and whorled nevoid hypermelanosis (LWNH) is a rare disorder of pigmentation characterized by hyperpigmented macules in a linear or whorled streaky configuration. Lesions are distributed mainly on the trunk and extremities, sparing the palms, soles, and mucosae.
What causes Hypomelanosis of Ito?
The exact cause of hypomelanosis of Ito is unknown. Many cases are associated with genetic mosaicism and sporadic gene mutations. Genetic mosaicism is the term for individuals who have two distinct cell lines in the body that developed because of a gene mutation that occurred during embryonic development.
Does pigmentary mosaicism go away?
Pigmentary mosaicism is a permanent color change in the skin. We are not able to change the genetic material to make the skin color the same.
What is Hypomelanosis of Ito syndrome genetic mosaic?
Hypomelanosis of Ito is a pigmentary mosaicism characterized by a clone of skin cells with decreased ability to produce pigment. The clinical pattern is characterized by hypopigmented streaks and whorls running along the lines of Blaschko, characteristically involving more than two body segments.
What is the difference between hypopigmentation and depigmentation?
While a decreased pigment production is reported as hypopigmentation, depigmentation has been defined as loss of pigment. In a similar way, partial lack of melanin is known as hypomelanosis while amelanosis is the total absence of melanin.
How can you tell the difference between nevus Depigmentosus and vitiligo?
Segmental vitiligo (SV) is a distinctive subtype of vitiligo characterized by unilateral, localized depigmentation of the skin. Nevus depigmentosus (ND) is defined as a congenital non-progressive hypopigmented lesion that is stable in its relative size and distribution throughout life.
How is Hypomelanosis treated?
Surgical techniques, from cryosurgery to dermabrasion, have been tried for idiopathic guttate hypomelanosis, with some success. Theoretically, cryotherapy would remove the damaged melanocytes, which would encourage normal melanocytes to replace them.
What is the most common extracutaneous involvement associated with pigmentary mosaicism?
The most frequently reported extracutaneous anomalies were skeletal deformities, seizures, mental retardation, dysmorphic facial features, and developmental delay.
Is pigmentary mosaicism genetic?
Pigmentary mosaicism is a term that describes varied patterns of pigmentation in the skin caused by genetic heterogeneity of the skin cells.