How does iron deficiency cause esophageal web?

How does iron deficiency cause esophageal web?

Although the pathogenesis of PVS remains largely unknown, the most probable mechanism of PVS is iron deficiency [3], leading to rapid loss of iron-dependent enzymes due to its high cell turnover. Loss of these enzymes causes mucosal degenerations, atrophic changes and web formation, which are associated with dysphagia.

Can iron deficiency cause trouble swallowing?

Plummer-Vinson syndrome is a condition that can occur in people with long-term (chronic) iron deficiency anemia. People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe (esophagus).

What are the symptoms of Plummer-Vinson syndrome?

Plummer-Vinson syndrome classically presents as a triad of iron-deficiency anemia, postcricoid dysphagia, and upper esophageal webs. [2] Long-standing iron deficiency anemia can present as dyspnea or difficulty breathing, tachycardia, weakness, pallor, and koilonychia or spoon nails.

Why is there anemia in Plummer-Vinson syndrome?

Etiopathogenesis of Plummer-Vinson syndrome is unknown. The most important possible etiological factor is iron deficiency. Other possible factors include malnutrition, genetic predisposition or autoimmune processes. Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation.

What has highest amount of iron?

Here are 12 healthy foods that are high in iron.

1. Shellfish. Shellfish is tasty and nutritious.
2. Spinach. Share on Pinterest.
3. Liver and other organ meats. Share on Pinterest.
4. Legumes. Share on Pinterest.
5. Red meat. Share on Pinterest.
6. Pumpkin seeds. Share on Pinterest.
7. Quinoa. Share on Pinterest.
8. Turkey. Share on Pinterest.

How do you get rid of an esophageal web?

Endoscopic procedures have also been used to treat esophageal webs. Endoscopic procedures can include endoscopic laser division or electrocautery to remove the web. Surgery is considered a last resort in the treatment of esophageal webs.

What causes webbing in throat?

Experts aren’t sure what causes esophageal rings and webs. The condition may be congenital (inherited) or may develop after birth. People with esophageal rings and webs commonly have reflux symptoms. When esophageal webs occur together with iron deficiency anemia the condition is known as Plummer-Vinson syndrome.

What causes webbing in the esophagus?

Common causes Some esophageal webs are inherited, or passed down genetically from parents to children. Others are thought to be associated with iron deficiencies, developmental abnormalities, inflammation, or autoimmune disorders. Medical conditions commonly associated with esophageal webs are described below.

What is another name for Plummer Vinson syndrome?

The association of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia is known as Plummer-Vinson syndrome (PVS) in the United States and Paterson-Brown Kelly syndrome in the United Kingdom.

Can anemia affect your throat?

Difficulty in swallowing or dysphagia is a common symptom. Esophageal webs are an infrequent cause of dysphagia. These have been found to occur in association with iron deficiency anemia (IDA) and dysphagia.

What causes an esophageal web?

How are esophageal webs associated with iron deficiency anemia?

Esophageal webs can be associated with iron deficiency anemia (Fig. 6-1). This is referred to as Plummer-Vinson syndrome. Brown-Paterson-Kelly syndrome is associated with anemia, esophageal web, and additional features of angular cheilitis and glossitis. Esophageal webs have also been associated with gastric inlet patches (Fig.

What can be done about Esophageal webs and rings?

In cases of PVS, treatment addresses all symptoms, including iron deficiency anemia, esophageal webs, and dysphagia. Sometimes, treating iron deficiency anemia reverses changes in the esophagus and relieves dysphagia.

Where are the webs located in the esophagus?

Esophageal webs are one or more thin horizontal membranes of squamous epithelium within the upper and mid esophagus. In contrast to rings, they rarely encircle the lumen but protrude from the anterior wall extending laterally but not posteriorly. Webs may be asymptomatic but do cause solid food dysphagia and can manifest at any age.

When does the esophageal web cause dysphagia?

An esophageal web is a thin mucosal membrane that grows across the lumen and may cause dysphagia. (See also Overview of Esophageal and Swallowing Disorders.) Rarely, webs develop in patients with untreated severe iron deficiency anemia; they develop even more rarely in patients without anemia.