What is the pharmacokinetics of Metformin?
Metformin undergoes renal excretion and has a mean plasma elimination half-life after oral administration of between 4.0 and 8.7 hours. This elimination is prolonged in patients with renal impairment and correlates with creatinine clearance.
How is Metformin metabolized?
Metformin is not metabolized. It is cleared from the body by tubular secretion and excreted unchanged in the urine; it is undetectable in blood plasma within 24 hours of a single oral dose. The average elimination half-life in plasma is 6.2 hours.
What is the physiological effect of Metformin?
General effects Metformin reduces liver (hepatic) production of glucose, decreases the intestinal absorption of glucose, and enhances insulin sensitivity by increasing both peripheral glucose uptake and utilization.
How does Metformin mechanism of action?
It is primarily used in patients with type 2 diabetes mellitus, and its main mechanism of action in this disease setting is inhibition of hepatic gluconeogenesis. Metformin interacts with complex I in the mitochondrial electron transport chain, thereby lowering cellular ATP levels and causing AMP accumulation.
Is there a pharmacokinetics pathway for metformin?
Pharmacokinetics pathway of metformin. Stylized cells depicting genes involved in the transport and clearance of metformin. A fully interactive version is available online at http://www.pharmgkb.org/pathway/PA165948259. PD, pharmacodynamics. Pharmacodynamics pathway of metformin.
How is the population mean of metformin calculated?
From published data on the pharmacokinetics of metformin, the population mean of its clearances were calculated.
What are the clinical pharmacokinetics of metformin biguanide?
Clinical pharmacokinetics of metformin The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus (NIDDM). Considerable renewal of interest in this drug has been observed in recent years. Metformin can be determined in biological fluids by vario …
What is the plasma elimination half life of metformin?
The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin. Metformin undergoes renal excretion and has a mean plasma elimination half-life after oral administration of between 4.0 and 8.7 hours.