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Which benzodiazepine is best for anxiety?

Which benzodiazepine is best for anxiety?

Benzodiazepines most commonly used to treat anxiety disorders are clonazepam (Rivotril)*, alprazolam (Xanax) and lorazepam (Ativan). Also used are bromazepam (Lectopam), oxazepam (Serax), chlordiazepoxide (once marketed as Librium), clorazepate (Tranxene) and diazepam (Valium).

How effective is benzodiazepine for anxiety?

Yes, and they usually work very well. In general, they are good for treatment of many types of anxiety problems over short (but not long) periods of time. Benzos are very helpful for treating panic attacks, at least for the first 1 to 2 months.

Why are benzodiazepines bad for anxiety?

Further, benzos can be the cause of the anxiety being experienced. Second, these drugs, especially when combined with other medications, can cause over-sedation or respiratory depression resulting in a risk of overdose.

What receptor do benzodiazepines target?

That the GABAA receptor is the main target for the central actions of benzodiazepines has been known for several decades (Costa et al., 1975; Haefely et al., 1975).

Do Benzos affect serotonin?

Although central serotonin neurons are thus implicated in the therapeutic actions of benzodiazepine tranquilizers, it is quite possible that the drugs actually act indirectly to reduce serotonin activity.

Do Benzos release dopamine?

When benzodiazepines limit the interneurons’ restraining influence, the dopamine-producing neurons release more dopamine. Benzodiazepines’ newly discovered mechanism for producing reward is comparable to those of opiates, cannabinoids, and GHB.

Why are Benzos bad for elderly?

Probably the most serious: falls and fractures, already a common danger for older people, because benzos can cause dizziness. They’re also associated with auto accidents, given that they cause drowsiness and fatigue. Moreover, “they have a negative effect on memory and other cognitive function,” says Dr.

When to use benzodiazepines for anxiety disorder?

The use of benzodiazepines is now reserved for second-line treatment or for short-term adjunctive use with SSRIs at the beginning of treatment to cover the lag period of 4–6 weeks before SSRIs become fully effective. With regard to nonpharmacological treatment of anxiety disorders, cognitive behavioral therapy is the best established.11,12

How does benzodiazepine affect the central nervous system?

This alteration, in turn, induces a conformational change in the GABA-A receptor’s chloride channel that hyperpolarizes the cell and accounts for GABA’s inhibitory effect throughout the central nervous system.3

Where are the binding sites of benzodiazepine receptors?

Each receptor complex has 2 GABA-binding sites but only 1 BZD-binding site. The benzodiazepine binding site is in a specific pocket at the pairing (intersection) of the α and γ subunits.

Why is amnesia a common side effect of BZD?

Specific Benzodiazepine Receptors. Therefore, amnesia is a common side effect of BZD use because the majority of GABA-A receptors contain the BZ1 receptor responsible for amnesia. 8 A major factor in predicting amnesia risk is lipid solubility; the greater the lipid solubility, the greater the risk of amnesia.

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