How do you administer Claforan?
Cefotaxime may be administered intravenously by bolus injection or by infusion, or by intramuscular injection. The dosage, route and frequency of administration should be determined by the severity of infection, the sensitivity of causative organisms and condition of the patient.
Why was cefotaxime discontinued?
7 Other companies that previously supplied cefotaxime made a business decision to discontinue production because of an increase in the price of the raw materials. The single-remaining supplier was unable to keep up with the demand for cefotaxime, leading to a national shortage.
What is another name for cefotaxime?
Cefotaxime
| Clinical data | |
|---|---|
| Pronunciation | /ˌsɛfəˈtækˌsiːm/ |
| Trade names | Claforan, others |
| Other names | cefotaxime sodium |
| AHFS/Drugs.com | Monograph |
Which group is cefotaxime?
Cefotaxime (CTX) is a beta-lactam antibiotic classified as a third-generation cephalosporin.
What drugs interact with cefotaxime?
View interaction reports for cefotaxime and the medicines listed below.
- Acetylsalicylic Acid (aspirin)
- Adrenalin (epinephrine)
- Augmentin (amoxicillin / clavulanate)
- B Complex 100 (multivitamin)
- Calcium 600 D (calcium / vitamin d)
- Chlorpheniramine (Allergy) (chlorpheniramine)
- Cipro (ciprofloxacin)
How do you administer cefotaxime IV?
Cefotaxime may be administered by intravenous infusion. 1-2 g are dissolved in 40-100 mL of Water for Injections B.P. or in the infusion fluids listed under Pharmaceutical Precautions. The prepared infusion should be administered over 20-60 minutes.
Is cefotaxime still available?
Reason for the Shortage Sanofi-Aventis manufactured Claforan for Hospira and is no longer making the product. Baxter discontinued Claforan in late-2015. Hikma is not currently marketing cefotaxime injection.
What is the difference between cefotaxime and ceftriaxone?
The two 3rd-generation cephalosporins ceftriaxone and cefotaxime share their antibacterial spectra, indications, and intravenous administration route, but they have different pharmacokinetic characteristics: ceftriaxone is administered once daily and has a 40% biliary elimination, while cefotaxime needs thrice daily …
How effective is cefotaxime?
Like other cephalosporins, cefotaxime is effective in treating patients with complicated urinary tract and lower respiratory tract infections, particularly pneumonia caused by Gram-negative bacilli. High response rates have also been achieved in patients with Gram-negative bacteraemia.
Is cefotaxime acidic or basic?
It is a member of 1,3-thiazoles, an oxime O-ether and a cephalosporin. It is a conjugate acid of a cefotaxime(1-). Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria.
What are the side effects of Claforan injections?
It works by stopping the growth of bacteria. This medication is given by injection into a muscle or vein as directed by your doctor. If given by injection into a vein, inject the drug slowly over at least 3 minutes to avoid possible serious side effects (such as irregular heartbeat).
What kind of vial does Claforan come in?
CLAFORAN is supplied as a dry powder in conventional and ADD-Vantage® System compatible vials, infusion bottles, pharmacy bulk package bottles, and as a frozen, premixed, iso-osmotic injection in a buffered diluent solution in plastic containers.
What do you need to know about sterile Claforan?
Claforan Description. Sterile Claforan (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate 72 (Z)-(o-methyloxime), acetate (ester).
Can you give Claforan through an IV line?
Claforan is injected into a muscle or into a vein through an IV. It is sometimes given through a central IV line placed into a large vein in your chest. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.