What is Sympathoplegic agent?
A sympatholytic (or sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS). They are indicated for various functions; for example, they may be used as antihypertensives.
What is the difference between sympathomimetic and sympatholytic?
A drug that enhances adrenergic function is known as a sympathomimetic drug, whereas a drug that interrupts adrenergic function is a sympatholytic drug.
Is Clonidine a sympathomimetic?
Adrenergic (Sympathomimetic) Drugs Methylation of this product into (11.1. 33) by the subsequent reaction with ethylendiamine gives clonidine (11.1. 34) [34–39]. Clonidine is a selective α2-adrenergic agonist.
Is adrenaline a sympathomimetic?
The primary endogenous agonists of the sympathetic nervous system are the catecholamines (i.e., epinephrine [adrenaline], norepinephrine [noradrenaline], and dopamine), which function as both neurotransmitters and hormones.
What are the side effects of sympathomimetics?
The adverse effects of sympathomimetics include:
- fine tremor, usually in the hands.
- nervous tension.
- peripheral vasodilation.
- sinus tachycardia.
- hypokalaemia after high doses – salbutamol.
- hypersensitivity, including paradoxical bronchospasm.
- impaired glucose tolerance in diabetics.
What are sympathomimetic drugs used for?
Sympathomimetic drugs mimic or stimulate the adrenergic nervous system, and they can raise blood pressure to alarming heights, particularly in hypertensive patients.
What type of drug is clonidine?
Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. Clonidine treats high blood pressure by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.
Is caffeine a sympathomimetic drug?
Caffeine and paraxanthine have similar sympathomimetic actions. The activity of paraxanthine needs to be considered in understanding the clinical pharmacology of caffeine, particularly with chronic, repetitive caffeine consumption.
What is another name for an adrenergic drug?
Examples of different vasopressors include: ephedrine. epinephrine. dopamine.
Which is the best description of a sympathomimetic drug?
Sympathomimetic drugs are agents which in general mimic responses due to stimulation of sympathetic nerves.
How are sympathomimetic drugs similar to catecholamines?
These agents are able to directly activate adrenergic receptors or to indirectly activate them by increasing norepinephrine and epinephrine (mediators of the sympathoadrenal system) levels. Chemically these drugs are catecholamines (Figure 1) or are structurally similar to catecholamines. The parent structure is β -phenylethylamine.
How are drugs related to the sympathetic nervous system?
Drugs that bind to these receptors and modulate or mimic the function of the sympathetic nervous system may be divided into those which augment the system ( sympathomimetics) and those which antagonize the system ( sympatholytics ).
Which is an important subgroup of the sympatholytic group?
Sympatholytics are an important group of antagonists used in cardiovascular and other conditions. These drugs are divided into primary subgroups on the basis of their receptor (α and β) selectivity.