What is the major cause of pancreatic cancer?

What is the major cause of pancreatic cancer?

Risk factors Smoking. Diabetes. Chronic inflammation of the pancreas (pancreatitis) Family history of genetic syndromes that can increase cancer risk, including a BRCA2 gene mutation, Lynch syndrome and familial atypical mole-malignant melanoma (FAMMM) syndrome.

What is the pathophysiology of pancreatic cancer?

Typically, pancreatic cancer first metastasizes to regional lymph nodes, then to the liver and, less commonly, to the lungs. It can also directly invade surrounding visceral organs such as the duodenum, stomach, and colon, or it can metastasize to any surface in the abdominal cavity via peritoneal spread.

What is an indicator of pancreatic cancer?

Belly or back pain. Pain in the abdomen (belly) or back is common in pancreatic cancer. Cancers that start in the body or tail of the pancreas can grow fairly large and start to press on other nearby organs, causing pain. The cancer may also spread to the nerves surrounding the pancreas, which often causes back pain.

What causes pancreatic cancer according to Mayo Clinic?

You will also receive emails from Mayo Clinic on the latest about cancer news, research, and care. It’s not clear what causes pancreatic cancer. Doctors have identified some factors that may increase the risk of this type of cancer, including smoking and having certain inherited gene mutations.

Is there a link between diet and pancreatic cancer?

A diet high in fat and meat (especially smoked or processed meat) has been linked to pancreatic cancer in animal studies. Eating a healthy diet rich in fruits and vegetables decreased pancreatic cancer risk in other studies. Still other studies suggest there’s no identifiable link between diet and pancreatic cancer.

What are the genes that cause pancreatic cancer?

Doctors have linked the condition to the BRCA1 and BRCA2 genes as well as genes that cause colorectal cancer and other health problems. These mutations cause up to 10% of pancreatic cancer cases. Many gene changes happen after you’re born.

Can a low lycopene diet cause pancreatic cancer?

Studies have shown low levels of these nutrients in some people who developed pancreatic cancer. That’s not proof that low levels of lycopene and selenium cause pancreatic cancer, though. Any diet that includes lean meat and red or yellow vegetables should provide adequate lycopene and selenium.