What is hemophilia trait?
Hemophilia is usually an inherited bleeding disorder in which the blood does not clot properly. This can lead to spontaneous bleeding as well as bleeding following injuries or surgery. Blood contains many proteins called clotting factors that can help to stop bleeding.
Is haemophilia A hereditary disease?
This change in a copy of the gene making factor VIII or factor IX is called a hemophilia allele. Most people who have hemophilia are born with it. It almost always is inherited (passed down) from a parent to a child.
What type of genetic mutation causes hemophilia?
Hemophilia A is caused by genetic changes ( mutations ) in the F8 gene. This gene is responsible for making the Factor VIII protein , an important protein that helps start the formation of blood clots.
Why is haemophilia a disease more common in males?
Because females have an extra X chromosome that functions as a “back-up,” these diseases afflict men more frequently than females. Because males only have one X chromosome, haemophilia is caused by a mutation in the factor VIII or IX gene. “Carriers” are females who have a mutation on one X chromosome.
What gender is hemophilia most common in?
Hemophilia is an inherited bleeding disorder primarily affecting males—but females can also have hemophilia.
What race is hemophilia most common in?
The average age of persons with hemophilia in the United States is 23.5 years. Compared to the distribution of race and ethnicity in the U.S. population, white race is more common, Hispanic ethnicity is equally common, while black race and Asian ancestry are less common among persons with hemophilia.
How is hemophilia inherited from father to daughter?
Suppose the X chromosome from her father has the gene for hemophilia. The daughter will not have hemophilia since the normal blood clotting gene from her mother is dominant. It won’t allow the instructions from the hemophilia gene to be sent. The daughter is called a carrier for hemophilia.
How is the F8 gene related to hemophilia B?
Changes in the F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene.
Can a female with hemophilia be heterozygous?
In rare cases, a female who is heterozygous can have bleeding symptoms that are just as serious as those of a male with hemophilia. A female can also have hemophilia if she inherits hemophilia alleles from both of her parents or if she inherits one hemophilia allele and her other X chromosomes is missing or does not work properly.
Can a person with no symptoms of hemophilia bleed?
Most women with the defective gene are simply carriers and experience no signs or symptoms of hemophilia. But some carriers can experience bleeding symptoms if their clotting factors are moderately decreased. The biggest risk factor for hemophilia is to have family members who also have the disorder. Complications of hemophilia may include: