What is the medicine cinacalcet used for?
CINACALCET (sin a CAL set) is used to treat patients with chronic kidney disease who are on dialysis. It is also used to treat high levels of calcium in the blood of patients with certain parathyroid gland problems.
Why is cinacalcet used in CKD?
Clinical trial studies have been performed ( 1 – 4, 6 – 13) ( Table 1). All of these studies have consistently shown that cinacalcet effectively reduces PTH, Ca, P, and calcium-phosphorus product (Ca × P) levels in patients who have stage 5 chronic kidney disease and receive dialysis.
Is there a generic for cinacalcet?
Cinacalcet (Sensipar) is available as a generic medication and may be significantly cheaper compared to the brand version. Unless there is a specific reason you need the brand, the generic medication will be a better value.
How quickly does cinacalcet work?
In phase I-II studies, the maximum effect of cinacalcet was achieved within 2–6 hours after administration, with a terminal half-life of 30–40 hours (30, 31).
What are the main side effects of cinacalcet?
Common side effects of Sensipar include:
- loss of appetite,
- muscle pain,
- mild chest pain,
- dizziness, or.
Can cinacalcet cause weight gain?
Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia.
Is Cinacalcet a phosphate binder?
Phosphate Binders Cinacalcet is a type II calcimimetic agent that binds the trans-membrane region of the calcium-sensing receptor, resulting in allosteric modulation. The change in receptor configuration makes it more sensitive to serum calcium and results in a reduction of serum PTH at lower levels of serum calcium.
Can I stop taking Cinacalcet?
Your doctor will probably start you on a low dose of cinacalcet and gradually increase your dose, not more than once every 2-4 weeks. Cinacalcet may help control your condition but will not cure it. Continue to take cinacalcet even if you feel well. Do not stop taking cinacalcet without talking to your doctor.
When is the best time to take cinacalcet?
It is usually taken once a day with food or shortly after a meal. To help you remember to take cinacalcet, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
When should you hold cinacalcet?
Does cinacalcet raise blood pressure?
The effect of cinacalcet was not modified by baseline pulse pressure (Pinteraction=0.44). In adjusted models, at 20 weeks cinacalcet resulted in a 2.2 mm Hg larger average decrease in systolic blood pressure (P=0.002) and a 1.3 mm Hg larger average decrease in diastolic blood pressure (P=0.002) compared with placebo.
Does cinacalcet reduce phosphate?
Cinacalcet reduced calcium values and increased phosphorus values, as can be seen in Figs 2 and 3. At baseline, the mean calcium value was 9.7 ± 0.7 mg/dl, which was reduced by 4% and 6% at 3 and 12 months respectively.