What is poloxamer 188 used for?

What is poloxamer 188 used for?

Poloxamer 188 (P188) is a nonionic linear copolymer having an average molecular weight of 8400 Daltons and is also referred to as PLURONIC F68, FLOCOR and RheothRx. The copolymer was approved by the FDA nearly 50 years ago as a therapeutic reagent to reduce viscosity in the blood before transfusions.

What is Shur Clens solution?

Shur-Clens® is a wound cleanser specifically designed for use on acute non-surgical traumatic wounds.

Is poloxamer 188 toxic?

In humans, the plasma concentration of Poloxamer 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. Poloxamers can cause hypercholesterolemia and hypertriglyceridemia in animals, but overall, they are relatively nontoxic to animals, with LD(50) values reported from 5 to 34.6 g/kg.

What is poloxamer 407 used for in mouthwash?

Poloxamer 407 is used in mouthwash to allow the blending of unblendable liquids. While research into the effects of poloxamer 407 on humans is ongoing, it is thought to be highly toxic and linked to breast cancer. This begs the question; why is it included in mouthwash? Saccharin is an artificial sweetener.

Is poloxamer 188 a surfactant?

Poloxamer 188 is a synthetic surfactant that is a multiblock copolymer. A P-188 molecule is composed of two blocks, 38 moieties each, of hydrophilic polyoxyethylene, flanking one block of 29 moieties of hydrophobic polyoxypropylene. It has a molecular weight of 8.4 kD, and, being 80% hydrophilic, it is water soluble.

Is poloxamer 184 bad for skin?

Poloxamer 184 is one of many types of surfactants used in these products. This substance is thought to be associated with moderate toxicity of non-reproductive organs, but little research suggests that it has any effect beyond mild skin irritation.

Is Pluronic a surfactant?

Gibco® Pluronic® F-68 is a non-ionic surfactant used to control shear forces in suspension cultures. Pluronic® F-68 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass.

Is Pluronic a poloxamer?

Poloxamer (Pluronic®) Poloxamers are another type of thermo–sensitive hydrogels with an ABA–type triblock structure (Fig. 4.4) (Kabanov et al., 2002).