How is cardene administered?
Instructions For Administration Administer Cardene I.V. by a central line or through a large peripheral vein. Change the infusion site every 12 hours if administered via peripheral vein [see Intravenous Infusion Site].
Can you IV push cardene?
Cardene I.V. is intended for intravenous use. Titrate dose to achieve the desired blood pressure reduction. Individualize dosage depending on the blood pressure to be obtained and the response of the patient. Initiate therapy at 50 mL/hr (5.0 mg/hr).
What is Cardene IV used for?
Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid control of blood pressure (BP). IV nicardipine was as effective as IV nitroprusside in the short-term reduction of BP in patients with severe or postoperative hypertension.
How do you titrate a cardene drip?
Administration: Nicardipine (Cardene) 50 mg in 250 ml NS (0.2 mg/ml) starting at 5mg/hr (25 ml/hr) IV infusion. Titrate to effect by increasing the rate of administration by 2.5 mg/hr every 5 minutes to a maximum of 15 mg/hr until desired blood pressure reduction is achieved.
Is esmolol a vasodilator?
Esmolol is frequently combined with direct vasodilators to provide a more desirable hemodynamic profile. The negative chronotropic effect produced by esmolol may be beneficial in patients with ischemic heart disease.
Is cardene a vasodilator?
It is an effective cerebral vasodilator, increasing cerebral blood flow and oxygen delivery.
Why is esmolol short acting?
Esmolol is an ultra–short-acting β1-selective adrenergic blocker. The onset of action of this agent is within 60 to 120 seconds and the duration of action is extremely short, about 10 to 30 minutes, because of its rapid metabolism by a specific plasma esterase.
Does esmolol affect heart rate?
By blocking the adrenergic activity of epinephrine and norepinephrine, it decreases inotropic contractility, heart rate, and conduction. Esmolol increases atrioventricular refractory time, decreases oxygen demand of the myocardium, and decreases atrioventricular conduction.
Does cardene cause bradycardia?
As a result, nicardipine generally does not cause the atrioventricular (AV) nodal blockade or bradycardia that is often de- scribed with nondihydropyridine calcium-channel blockers [3,4]. Experiments have demonstrated, however, that nicardipine can cause profound bradycardia when the sympathetic surge is blunted.
Which is the shortest acting beta-blocker?
Esmolol and landiolol are ultra-short-acting intravenous beta-blockers. Both drugs have high cardioselectivity (beta1/beta2 selectivity of esmolol : 33, landiolol: 255) and short elimination half time (esmolol : 9 min, landiolol : 4 min).
Can esmolol be given IV push?
Initial dose 250 to 500 mcg/kg undiluted IV push over 1 minute followed by maintenance infusion (50 mcg/kg/min for 4 mins). May repeat same IV push and increase infusion to 100 mcg/kg/min.
Does cardene slow heart rate?
By slowing calcium influx into cardiac muscle cells, calcium channel blockers tend to reduce the force of cardiac contraction, thus reducing cardiac work and the vigor of the heart beat.
When to use Cardene i.v.premixed injection?
Cardene I.V. Premixed Injection is available as a single-use, ready-to-use, iso-osmotic solution for intravenous administration. No further dilution is required. Inspect Cardene I.V. Premixed Injection visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
How is the dilution of Cardene i.v.done?
Dilution: Cardene I.V. is administered by slow continuous infusion at a CONCENTRATION OF 0.1 MG/ML. Each ampul (25 mg) should be diluted with 240 mL of compatible intravenous fluid (see below), resulting in 250 mL of solution at a concentration of 0.1 mg/mL.
What’s the best dosage for Cardene I.V?
Cardene I.V. is intended for intravenous use. Titrate dose to achieve the desired blood pressure reduction. Individualize dosage depending on the blood pressure to be obtained and the response of the patient.
Can you take nicardipine hydrochloride with Cardene IV?
CARDENE IV (nicardipine hydrochloride in These highlights do not include all the information needed to use CARDENE IV safely and effectively. See full prescribing information for CARDENE IV. Do not use in patients with advanced aortic stenosis ( 4.1 ).