Why are they called the immunoglobulin superfamily of cellular adhesion molecules?
Ig domains are named after the immunoglobulin molecules. They contain about 70-110 amino acids and are categorized according to their size and function. Ig-domains possess a characteristic Ig-fold, which has a sandwich-like structure formed by two sheets of antiparallel beta strands.
Are integrins adhesion molecules?
In blood cells, as we have seen, integrins also serve as cell-cell adhesion molecules, helping the cells bind to other cells, as well as to the extracellular matrix.
What is the basic structure of immunoglobulin superfamily?
The Ig superfamily constitutes the other dominating family of CAMs in the nervous system. Its characteristic feature is the Ig domain that consists of 90–100 amino acids arranged in seven antiparallel β-pleated sheets that fold into a globular structure.
Which molecules are called immunoglobulin superfamily?
What are immunoglobulin superfamily cell adhesion molecules? Members of the Immunoglobulin superfamily include vascular and neural cell adhesions molecules (VCAM and NCAM), intercellular adhesion molecules (ICAM) and the Nectins and nectin-like (Necl) proteins.
Where are cell adhesion molecules found?
Cell adhesion molecules (CAMs) are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion (Aplin et al., 1998).
What are members of immunoglobulin superfamily cell adhesion molecules?
What are immunoglobulin superfamily cell adhesion molecules? Members of the Immunoglobulin superfamily include vascular and neural cell adhesions molecules (VCAM and NCAM), intercellular adhesion molecules (ICAM) and the Nectins and nectin-like (Necl) proteins.
What are the members of the Ig superfamily?
The Ig superfamily is a large group of cell surface molecules that includes members such as: vascular cell adhesion molecules (VCAM) neural cell adhesion molecules (NCAM) intercellular adhesion molecules (ICAM) nectin and nectin-like (Nec1) family
What is the role of cell adhesion molecules?
Cell adhesion molecules (CAMs) facilitate these interactions and are essential during development and for maintaining the integrity of tissue architecture in adults [1, 2]. CAMs include cadherins, integrins, selectins, and the immunoglobulin superfamily (IgSF). In normal tissue, CAM expression is tightly regulated.
What are the structural domains of the IGSF?
Proteins of the IgSF possess a structural domain known as an immunoglobulin (Ig) domain. Ig domains are named after the immunoglobulin molecules. They contain about 70-110 amino acids and are categorized according to their size and function.