Is denosumab better than alendronate in the treatment of osteoporosis?

Is denosumab better than alendronate in the treatment of osteoporosis?

These RCTs, conducted in postmenopausal women, regardless of prior treatment for osteoporosis, both found denosumab to be more efficacious than alendronate in increasing BMD, possibly the best proxy outcome for subsequent fracture risk.

Does denosumab lower immune system?

Denosumab is an antibody-based medication, but it doesn’t suppress your immune system. This means it doesn’t increase your risk of complications from the coronavirus. This is unlike other antibody-based medications used to treat diseases like rheumatoid arthritis.

Does denosumab cause hair loss?

According to published records, side effects associated with denosumab include musculoskeletal pain, arthralgia, cystitis, and nasopharyngitis. Regarding the impact of denosumab on hair, in the phase 1 trial hair loss was observed in 11% of Japanese women treated for breast cancer–related bone metastases.

What is the difference between Fosamax and Prolia?

Fosamax (alendronate sodium) and Prolia (denosumab) are used to treat and prevent osteoporosis. Fosamax is also used to treat Paget’s disease. Fosamax and Prolia belong to different drug classes. Fosamax is a bisphosphonate and Prolia is a monoclonal antibody.

What is the name of the medicine denosumab?

Prolia is the brand name for the generic medication denosumab. In the body, Prolia blocks RANKL, a protein that’s important for the cells that break down bone. Prolia keeps RANKL from binding to its receptor, which prevents these cells from breaking down bone.

How is Fosamax used to treat osteoporosis?

Fosamax (alendronate sodium) is a bisphosphonate that is a specific inhibitor of osteoclast -mediated bone resorption used to both treat and prevent osteoporosis, and to treat Paget’s disease.

Which is better for you Boniva or Fosamax?

Based on several studies, we know that Fosamax also reduces the risk of hip fractures and nonvertebral fractures. But we aren’t quite sure whether Boniva reduces the risk of hip or nonvertebral fractures. Because of this, clinical guidelines generally recommend Fosamax over Boniva.