Common questions

Can chloroquine injection be given intravenously?

Can chloroquine injection be given intravenously?

In cases of severe malaria chloroquine phosphate is frequently given–diluted or undiluted–by the intravenous route. It is known that cardiac arrhythmias and hypotension may complicate such therapy, but cardiac arrest is not a well recognised hazard.

Can quinine injection be given intramuscularly?

Alternative pre-referral: Intramuscular quinine is recommended when IV infusion is not possible. Undiluted quinine injection is painful when given by IM, so it is therefore best to administer in a buffered formulation or diluted to 60-100 mg/mL.

When do you administer chloroquine?

Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week.

How do you dilute quinine for intramuscular injections?

Quinine should be diluted (1/2 or 1/5). For the loading dose, administer half the dose into each thigh.

Is chloroquine IM or IV?

Chloroquine can be administered by intramuscular or subcutaneous injection at a dose of 3.5 mg base/kg 6-hourly up to a total dose of 25 mg base/kg.

What is the work of chloroquine injection?

Chloroquine phosphate is used to prevent and treat malaria. It is also used to treat amebiasis. Chloroquine phosphate is in a class of drugs called antimalarials and amebicides. It works by killing the organisms that cause malaria and amebiasis.

Can quinine be given IV?

Quinine must never be given by intravenous bolus injection, as lethal hypotension may result. Quinine dihydrochloride should be given by rate-controlled infusion in saline or dextrose solution.

How do you give an intramuscular injection?

How to administer an intramuscular injection

  1. Follow these steps for a safe intramuscular injection:
  2. Remove the cap.
  3. Draw air into the syringe.
  4. Insert air into the vial.
  5. Withdraw the medication.
  6. Remove air bubbles.
  7. Insert the needle.
  8. Check for blood.

What is the mechanism of action of chloroquine?

Drug Indication Therapeutic Uses Clinical Trials FDA Orange Book Chloroquine is the prototypical antimalarial agent with a mechanism that is not well understood. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities.

When did the FDA approve chloroquine for adults?

The FDA had approved an Emergency Use Authorization (EUA) on March 28, 2020 to allow distribution of chloroquine for the treatment adults and adolescents who weigh at least 110 pounds (50 kg) and who are hospitalized with COVID-19, but who are unable to participate in a clinical study.

What is the plasma concn of chloroquine daily?

Oral administration of 310 mg of chloroquine daily reportedly results in peak plasma concn of about 0.125 ug/mL. If 500 mg of chloroquine is administered once weekly, peak plasma concn of the drug reportedly range from 0.15-0.25 ug/mL and trough plasma concn reportedly range from 0.02-0.04 ug/mL.

What to do if you have side effects from chloroquine?

If you experience irregular heartbeats, dizziness, or fainting while taking chloroquine, call 911 for emergency medical treatment. If you have other side effects, be sure to tell your doctor.

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