What is the pathogenesis of systemic lupus erythematosus?
Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE.
What is Systemic Lupus Erythematosus Pubmed?
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with multisystemic involvement. The disease has several phenotypes, with varying clinical presentations in patients ranging from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement.
What is SLE pathology?
Systemic lupus erythematosus (SLE) is a syndrome characterized by organ damage that results from the deposition of immune complexes. The immune complexes form when autoantibodies are made against the nucleic acids and protein constituents of the nucleus of cells.
How does SLE develop?
It’s likely that lupus results from a combination of your genetics and your environment. It appears that people with an inherited predisposition for lupus may develop the disease when they come into contact with something in the environment that can trigger lupus. The cause of lupus in most cases, however, is unknown.
What is predisposition to systemic lupus erythematosus?
The genetic contribution to the development of SLE is considerably high, which is estimated to be 66% of heritability in twin studies. The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. The disease tends to occur in families.
What cells are involved in systemic lupus erythematosus?
In individuals with lupus, both B cells and T cells become overactive. The two main consequences of this increased activity are the production of autoantibodies (antibodies that recognize and destroy the body’s own cells) and inflammation that can lead to long-term, irreversible scarring.
Why SLE is more common in females?
Conclusions: The increased frequency of SLE among women may be attributed to differences in the metabolism of sex hormones and/or GnRH. Though less common in men, when it does occur SLE tends to run a more severe course-an important consideration in the diagnosis and follow-up of male patients with SLE.
What is the patho-aetiology of systemic lupus erythematosus?
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility.
Where is systemic lupus erythematosus located in Hong Kong?
Dr C C Mok, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong; [email protected] The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive.
Why is machine learning important for systemic lupus?
Machine learning algorithms may be necessary to integrate and interpret big data analyses and have the potential to unlock the mysteries of SLE. Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes damage to multiple organ systems.
Which is pathogenic event leads to lupus nephritis?
This Review discusses the genetic insights and molecular mechanisms for key pathogenic contributors in SLE and lupus nephritis. We have categorized the genes identified in human studies of SLE into one of four pathogenic events that lead to lupus nephritis.