What does metabolism of purine and pyrimidine produce?
The purine and pyrimidine bases released are either degraded or salvaged for reincorporation into nucleotides. Pyrimidine catabolism, however, does produce beta-alanine, and the endproduct of purine catabolism, which is uric acid in man, may serve as a scavenger of reactive oxygen species.
What disease is associated with pyrimidine metabolism?
Lesch-Nyhan syndrome is a metabolic disorder of purine and pyrimidine metabolism. It is an X-linked deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT), encoded by the HPRT1 gene.
How do purines and pyrimidines affect the structure of DNA?
Matching base pairs ( purines and pyrimidines ) form hydrogen bonds. A and T have two sites where they form hydrogen bonds to each other. For each of the four nitrogenous bases a specific tautomeric form must be incorporated for proper bonding , stability and attachment to the sugar phosphate backbone of DNA.
What is purine and pyrimidine synthesis?
Introduction. Purine and pyrimidine nucleotides are major energy carriers, subunits of nucleic acids and precursors for the synthesis of nucleotide cofactors such as NAD and SAM.
Is a disorder of purine metabolism?
The most commonly encountered disorder of purine metabolism is gout. This affects roughly 1–2% of the population and is characterized by hyperuricemia with urate crystal deposition resulting in nephrolithiasis and inflammatory arthritis (Schlesinger, 2010).
What are 2 similarities and 2 differences between purine and pyrimidines?
Purines vs. Pyrimidines
|Structure||Double carbon-nitrogen ring with four nitrogen atoms||Single carbon-nitrogen ring with two nitrogen atoms|
|Source||Adenine and Guanine in both DNA and RNA||Cytosine in both DNA and RNA Uracil only in RNA Thymine only in DNA|